This Domain Monitor digs deeper into the evidence-based medicine debate to see if there are other ways to frame the discussion and could open up ways for data science to uncover local patterns beyond global means that could provide physicians with the data they need to practice the art of medicine while also being scientifically based and evaluated. The timeliness of this debate is important; as interest in precision medicine and personalized approaches to therapy grows, we will need to manage the tensions that could possibly emerge between Population Health Management and the world of n=1.

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